Category: Toxicology

By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

This quantity represents the complaints of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park lodge and hotel in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to provide this quantity to the ophthalmic neighborhood, specifically people with an important curiosity in ocular toxicol­ ogy. The 5th Congress used to be built round issues on the subject of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt concerns on the subject of using replacement equipment for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo versions in addition to assorted animal versions. the result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or lower than improvement and to varied drug or actual results on diverse ocular tissues. whereas the focal point of this court cases is on ocular results of substances or different fabrics, a few of the contributions take care of themes that experience a wider curiosity. The workshop about the use of alternative version platforms and the alternative of the easiest animal version for drug checking out covers a variety of pursuits that ex­ has a tendency a ways past particular ocular results. this is often very true within the region of other tools and within the selection of the simplest animal version for exam of alternative affliction entities.

By Mehdi Boroujerdi

Pharmacokinetics and Toxicokinetics presents an summary of pharmacokinetics and toxicokinetics in a understandable, interrelated, and utilized demeanour. It integrates the foundations held in universal through either fields via a logical and systematic strategy.

The booklet provides mathematical descriptions of physiological tactics hired in numerous techniques to PK/TK modeling. It makes a speciality of emphasizing basic ideas and ideas, instead of remoted observations. particularly, the ebook is an attempt to mixture the pharmaceutical and toxicological elements of either fields.

The systematic compilation of mathematical techniques and methodologies permits readers to choose proper thoughts and techniques for his or her learn, medical or regulatory judgements, or for delivering improve classes and seminars. this can be a useful source for scientists within the pharmaceutical sciences, scientific sciences, and environmental wellbeing and fitness sciences, in addition to these taken with drug discovery and improvement.

By Curtis D. Klaassen

The so much entire, relied on reference textual content overlaying the whole span of clinical toxicology

A Doody's middle identify crucial buy for 2011!

"This reference stands on my own because the easy textual content within the box of toxicology. This authoritative reference is written by way of many wonderful pros within the box, and provides transparent, concise descriptions of the most important innovations in toxicology. it's vast and whole, overlaying a vast diversity of themes in enough element. either as a reference and as an instructional instrument, this ebook exceeds its aim of serving as a reference for toxicologists, different scientists, and scholars of the self-discipline. three Stars."--Doody's overview Service

Long demonstrated because the most excellent within the box, Casarett & Doull's Toxicology equips you with an unsurpassed knowing of contemporary toxicology, together with the rules, suggestions, mechanisms, and modes of inspiration which are the basis of the self-discipline. the hot 7th version positive factors is up to date all through and comprises many new members and new content material on chemical terrorism.

By Wayne Landis, Ruth Sofield, Wayne G. Landis, Ming-Ho Yu

Advent to Environmental ToxicologyEnvironmental Toxicology as an Interdisciplinary ScienceA short background and organisations in Environmental ToxicologyInteractions and Connections of Environmental Toxicology to the administration of Ecological SystemsLegislationIntroduction to This TextbookStudy QuestionsFrameworks and Paradigms for Environmental ToxicologyThe FundamentalsModelsFundamental types for Environmental ToxicologyThe Classical perspective for Classifying Toxicological EffectsChemical Physical-Chemical CharacteristicsBioaccumulation/Biotransformation/BiodegradationReceptors and the M. Read more...

By J. Thomas August (Eds.)

By Institute of Medicine, Committee on R&D Needs for Improving Civilian Medical Response to Chemical and Biological Terrorism Incidents

The hazard of household terrorism this present day looms greater than ever. Bombings on the international alternate heart and Oklahoma City's Federal development, in addition to nerve fuel assaults in Japan, have made it tragically visible that American civilians needs to be prepared for terrorist assaults. What can we want to know to assist emergency and clinical body of workers arrange for those assaults? Chemical and organic Terrorism identifies the R&D efforts had to enforce concepts in key parts: pre-incident intelligence, detection and identity of chemical and organic brokers, protecting garments and gear, early popularity inhabitants has been covertly uncovered to a pathogen, mass casualty decontamination and triage, use of vaccines and prescribed drugs, and the mental results of terror. particular pursuits for software program improvement also are pointed out. The booklet addresses the variations among a organic and chemical assault, the distinctive demanding situations to the army and civilian scientific groups, and different broader matters. This e-book might be of severe curiosity to someone excited by civilian preparedness for terrorist assault: planners, directors, responders, doctors, public health and wellbeing and emergency group of workers, and know-how designers and engineers.

By Donald G. Robertson, John Lindon, Jeremy K. Nicholson, Elaine Holmes

Filling a niche within the literature, this reference offers complete insurance of all facets of metabonomics know-how together with analytical and biologic concerns, in addition to sections on chemometrics-devoting complete chapters to serious subject matters similar to biomarkers, metabolite identity, and using magic attitude spinning for tissue metabonomics. It comprises various examples illustrating innovations and strategies for the identity of endogenous and xenobiotic metabolites. offering crucial instruments for the toxicologist using metabonomic applied sciences, this advisor offers a transparent define of using metabonomics within the protection evaluation of latest chemical entities. OTI number 1 1963

By Helmut Greim, Richard Albertini, Diana Anderson, Mathieu Vinken, Lutz Mueller, Boris Zhivotovski, Hermann M Bolt, Grigory Dianov, Susan Wallace, R J Preston, Eugenia Dogliotti, B. Kaina, Gary Williams, M Ljungman, W Dekant, P.C. Hanawalt

Content material: creation: the reason for thresholds for genotoxic cancer causing agents; half 1. Threshold results saw in experimental reviews: Mechanisms chargeable for the chromosome and gene mutations riding carcinogenesis: implications for dose-response features of mutagenic cancer agents; Dose-effect relationships of DANN-reactive liver cancer causing agents; DNA alkylation and service after EEMS publicity: the place do the thresholds for mutagenic/clastogenic results come up? half 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxing of endogenously produced mutagenic cancer agents holding mobile homeostasis; part 2 detoxifying enzymes and anti-oxygen security mechanisms within the inactivation of genotoxic cancer causing agents; half three. DNA fix: effects and service of oxidative DNA harm; The plasticity of DNA harm reaction in the course of cellphone differentiation: pathways and results; Tumor suppressor protein-mediated law of base excision fix based on DNA harm; half four. Apoptosis: Survival and loss of life recommendations in cells uncovered to genotoxin; diversified modes of mobilephone loss of life caused via DNA harm; Transcriptional inhibition by way of DNA harm as a set off of mobile loss of life; half five. Epigenetic mechanisms: The interaction among epigenetics and hole junctionional intercellular verbal exchange; Index

By Carson R. Harris MD

The Toxicology instruction manual offers you easy accessibility to universal ingestions you are prone to see within the Emergency division. Chapters protecting insecticides, Cardiovascular medicinal drugs, medicinal drugs of Abuse, and lots of extra placed crucial subject matters correct at your fingertips. every one bankruptcy follows an identical association, making info speedy and straightforward to find.Bulletted layout makes info effortless to entry and readChapters stick to an analogous association - advent and assessment, ingredients, Toxicity and medical Presentation, Laboratory review, therapy, certain issues, Admission Criteria/Disposition, Pearls and Pitfalls, References/Suggested Readings - helps you to locate info quicklyFull of scientific pearls, together with Toxicology Mnemonics and Acronyms, The Toxicology Lab, Antidotes, road Names for medicines of Abuse, and more!Chapters logically equipped by means of forms of drug like insecticides, Cardiovascular medicinal drugs, and medication of Abuse for ease of use.

By World Health Organization

This new quantity within the Environmental healthiness standards sequence offers an outline of dermal absorption and its attention within the threat evaluation of chemical compounds. It describes the tools to be had to evaluate dermal absorption, the importance of pores and skin as a course of publicity and the translation of result of dermal absorption reviews for threat evaluation. moreover, it offers and discusses present issues of curiosity within the box of dermal absorption.