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By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)
This quantity represents the complaints of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park lodge and hotel in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to provide this quantity to the ophthalmic neighborhood, specifically people with an important curiosity in ocular toxicol ogy. The 5th Congress used to be built round issues on the subject of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt concerns on the subject of using replacement equipment for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo versions in addition to assorted animal versions. the result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or lower than improvement and to varied drug or actual results on diverse ocular tissues. whereas the focal point of this court cases is on ocular results of substances or different fabrics, a few of the contributions take care of themes that experience a wider curiosity. The workshop about the use of alternative version platforms and the alternative of the easiest animal version for drug checking out covers a variety of pursuits that ex has a tendency a ways past particular ocular results. this is often very true within the region of other tools and within the selection of the simplest animal version for exam of alternative affliction entities.
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To explore this possibility, we investigated the status of PSSG and PSSC in several oxidant-induced cataract models in vivo and in vitro, including naphthalene,32 ultraviolet radiation,33 photochemical/ 4 diquat/ 5 hyperbaric oxygen. 24 Here, not only is the oxidant in each model different, but some of the animals used are also different. In all of these models higher levels of protein-thiol mixed disulfides have been found in the lens with an increasing level from the precataractous stage to the mature cataract stage.
G + C =GS03 H + CS0 3H. Cor =cortex, Nuc =nucleus 36 M. F. Lou Table 5. 2 "'Data is expressed as ~lmoles/gram dry lens weight. WS = water soluble proteins, WI ::;: water insoluble proteins. C/G = CS0 3 H/GS0 3H. CS0 3 H = protein bound cysteine released as cysteic acid. GS0 3H = protein bound GSH released as glutathione sulfonic acid. WS/WI = dry weight of the water soluble fraction I dry weight of the water insoluble fraction. 4. 24 This pattern is in agreement with the distribution pattern of pssa in the lens as described above.
102. Laniado-Schwartzman M, Stoltz RA, Rapacon MM, Lavrovsky Y, Conners MS, Abraham NG. Rapid and stereospecific activation of NFkB by a corneal angiogenic eicosanoic in microvesse! endothelial cells. Invest Ophthalmol Vis Sci 1995; 3S: 1466. 103. Stoltz RA, Conners MS, Gerritsen ME, Abraham NG, Laniado-Schwartzman M. Direct stimulation of Iimbal microvessel endothelial cell proliferation and capillary fonnation in vitro by a corneal-derived eicosanoic. Am J Patho11996; 148: 129-139. 104. Stoltz RA, Abraham NG, Laniado Schwartzman M.