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By Manfred Georg Krukemeyer (Editor), et al.
This booklet is for making all features of transplantation drugs and its advantages for sufferers extra available to medical professionals in inner most perform. brief and transparent chapters on theoretical fundamentals - via criminal, moral and correct as much as philosophical questions - plus chapters facing all significant organs and teams of organs and which take on the complicated query of immune response, give you the physician with solutions to all his questions about the topic of transplantation. specific emphasis is put on rehabilitation.
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Extra info for Transplantationsmedizin : ein leitfaden für den praktiker
Example text
Alsbald nach Inkrafttreten des Gesetzes hatte sich das Bundesverfassungsgericht mit einigen Aspekten der Neuregelung zu befassen. Mehrere Verfassungsbeschwerden gegen das Hirntodkonzept, die erweiterte Zustimmungslösung und die personelle Beschränkung der Lebend-Organspende wurden jedoch nicht zur Entscheidung angenommen und fanden damit jedenfalls implizit das höchstrichterliche Placet aus Karlsruhe Ϫ was nicht ausschließt, dass der Gesetzgeber in verfassungskonformer Weise auch andere Optionen hätte wahrnehmen können.
Zunächst wird eine niedrig auflösende (2-stellige) molekulargenetische Testung durchgeführt; ergibt sich hierbei ebenfalls eine Homozygotie, wird eine hoch auflösende (4-stellige) molekulargenetische Testung angeschlossen. Alternativ kann eine Homozygotie über eine Segregation der HLA Merkmale innerhalb der Familie bestätigt werden (vgl. Abb. 3). Die Befundmitteilung an die Transplantationszentren sowie die Vermittlungsstelle erfolgt gemäß der aktuellen WHO-Nomenklatur. Ein Nachweis von Alloantikörpern beim Patienten erfolgt vor Aufnahme in die Warteliste und wird mindestens quartalsweise wiederholt.
Beide Antikörper binden an die α-Kette (CD25) des trimeren Interleukin-2-Rezeptors und blockieren die Interleukin-2-vermittelte Vermehrung von aktivierten T-Lymphozyten (Abb. 7). Hierbei wird die Immunantwort gegen das Transplantat, aber auch die adaptive Immunantwort gegen Infektionserreger herabgesetzt. Während der Behandlung ist deshalb ein Schutz vor Infektionen besonders wichtig. MabThera“ (Rituximab) ist ein chimärisierter Antikörper, der gegen das CD20-Molekül auf B-Lymphozyten gerichtet ist.