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By Ray H. Liu
The research of substances and their metabolites in organic media at the moment are anticipated to oftentimes in attaining ± 20% accuracy within the ng/mL focus point. consequently, the supply and the choice of caliber ion-pairs designating the analytes and their isotopically classified analogs (ILAs) are very important concerns achieve the accuracy of quantitation effects. aiding scientists with this strategy, Quantitation and Mass Spectrometric info of gear and Isotopically categorized Analogs presents an incredibly worthwhile reference for labs fascinated by the research of healing and abused medicines. half one in all this accomplished quantity illustrates ways, mechanisms, and demanding situations bearing on using isotopic analogs as inner criteria for drug quantitation. the second one part is a scientific compilation of full-scan mass spectra of substances and their analogs, as dad or mum compounds and as derivatives as a result of quite a few chemical derivatization methods, typically encountered in today’s labs. in line with the mass spectra facts awarded within the moment part, half 3 offers corresponding tables of ion-pairs that can probably be tailored to designate the medication and their isotopic analogs within the analytical procedures. Relative caliber of those ion-pairs (cross-contribution to the depth of those ions via their isotopic analogs) is integrated in those tables. With greater than 1500 full-scan mass spectra and easy accessibility facts tables, this article represents the authors’ years of labor compiling mass spectra of the numerous chemical derivatization sorts of medicinal drugs, their metabolites, and their isotopically classified opposite numbers. The remarkable scope of this compilation makes it a severe one-stop reference for these excited about drug analyses of organic specimens and interpretation of effects.
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Extra resources for Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs
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30. Jones JB, Mell LD: A simple wash procedure for improving chromatography of HFAA derivatized amphetamine extracts for GC/MS analysis; J Anal Toxicol 17:447; 1993. 31. Czarny RJ, Hornbeck CL: Quantitation of methamphetamine and amphetamine in urine by GC/MS Part. II. Derivatization with 4-carbethoxyhexafluorobutyl chloride; J Anal Toxicol 13:257; 1989. 32. Ropero-Miller JD, Lambing MK, Winecker RE: Simultaneous quantitation of opioids in blood by GC-EIMS analysis following deproteination, detautomerization of keto analytes, solid-phase extraction, and trimethylsilyl derivatization; J Anal Toxicol 26:524; 2002.
Mass spectra of commonly abused drugs and their isotopically labeled analogs in various derivatization forms — Stimulants ...................................................................................................................................................................................... 35 Figure II. Mass spectra of commonly abused drugs and their isotopically labeled analogs in various derivatization forms — Opioids ..........................................................................................................................................................................................
Each table includes all derivatization groups that have been attempted. The order of appearance of these derivatization groups in each table is the same as those listed in Table 2-2 in this chapter. CONCLUDING REMARKS Following a review on: (a) the structural features of commonly encountered drugs; (b) commercially available isotopically labeled analogs of these drugs; and (c) commonly utilized chemical derivatization approaches, the authors have carried out a series of chemical derivatization experiments and collected a set of full-scan mass spectra and CC data for ion-pairs with potential for designating the analytes and their ILAs serving as the ISs.