
By John Timbrell
This can be a compilation of questions with solutions for college kids of toxicology. The questions are a mix of brief solution, problem-solving, facts interpretation and a number of selection and canopy all of the significant components of toxicology, together with mechanisms of toxicity, poisonous responses, elements affecting the toxicity of compounds and the metabolism and disposition of poisonous compounds. The e-book also needs to be important for certified toxicologists and scientists operating in similar parts who're getting ready for inner examinations.
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B) The drug metabolising enzymes are important in toxicology because they are often involved in detoxication of foreign and potentially toxic compounds. Therefore inhibition of these enzymes can result in increased exposure of the body to the chemical and prolonged half-life. This may lead to increased toxicity to the compound if the parent chemical is toxic. However, if a metabolite is toxic then inhibition of these enzymes may lead to decreased toxicity. (c) Glutathione is a tripeptide found in most mammalian tissues, but especially the liver.
This may lead to increased toxicity to the compound if the parent chemical is toxic. However, if a metabolite is toxic then inhibition of these enzymes may lead to decreased toxicity. (c) Glutathione is a tripeptide found in most mammalian tissues, but especially the liver. Here it has a concentration of 5 mM or greater. The amino acids which constitute glutathione are glutamic acid, cysteine and glycine. The cysteine has a free SH (sulphydryl) group which is crucial to the function of glutathione.
When a drug is bound to tissue components or sequestered in a tissue such as adipose tissue, the plasma level may be very low. Therefore the calculation of volume of distribution (VD=dose/plasma level) yields a value which may be higher than the total body water. The volume of distribution may be equal to the total body water but this is not always the case. A3. (d) Pulmonary bronchi. Although particles of this size will be deposited in various parts of the respiratory system, it has been shown that the pulmonary bronchi will retain the greatest proportion.