Quaternary Stereocenters: Challenges and Solutions for by Jens Christoffers, Angelika Baro, Steven V. Ley

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By Jens Christoffers, Angelika Baro, Steven V. Ley

Filling the space within the literature, this publication offers every little thing there's to understand approximately this subject. by way of comprehensively overlaying the quaternary stereocenters present in various vital and valuable molecules in pharmaceutical and medicinal functions, in addition to in millions of normal items, the e-book offers the information chemists have to synthesize tough molecules with quite a few applications.A needs to for natural chemists in academia, the pharmaceutical and medicine.From the Contents:Important ordinary ProductsImportant prescribed drugs and IntermediatesAldol ReactionsMichael Reactions and Conjugate AdditionsCycloaddition ReactionsRearrangement ReactionsAlkylation of Ketones and IminesAsymmetric Allylic AlkylationAsymmetric pass Coupling and Heck ReactionsPhase move CatalysisEnzymatic MethodsRadical Reactions

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Aratani, F. Nakatsubo, T. Goto, S. Inoue, H. Tanino, S. Sugiura, H. Kakoi, J. Am. Chem. Soc. 1972, 94, 9219; (b) N. Ohyabu, T. Nishikawa, M. Isobe, J. Am. Chem. Soc. 2003, 125, 8798; (c) T. Nishikawa, D. Urabe, M. Isobe, Angew. Chem. Int. Ed. 2004, 43, 4782; (d) T. Nishikawa, M. Asai, N. Ohyabu, N. Yamamoto, M. Isobe, Angew. Chem. Int. Ed. 1999, 38, 3081. 52 D. F. Taber, T. E. Chritos, A. L. Rheingold, I. A. Guzei, J. Am. Chem. Soc. 1999, 121, 5589. 23 c01 7/19/05 6:57 PM 24 Page 24 1 Important Natural Products 53 A lipase-catalyzed enantioselective desymmetrization of prochiral diol was recently employed to construct a spiro-quaternary center in an antitumor antibiotic fredericamycin analogue; A.

References 1 Some recent reviews on the synthesis of quaternary centers in natural products: (a) C. J. Douglas, L. E. Overman, PNAS 2004, 101, 5363; (b) E. A. Peterson, L. E. Overman, PNAS 2004, 101, 11943. 2 A detailed review on the progress of stereoselective formation of quaternary carbon centers; I. Denissova, L. Barriault, Tetrahedron 2003, 59, 10105. 3 (a) B. Weber, D. Seebach, Tetrahedron 1994, 50, 6117; (b) L. -B. Yu, Chem. Rev. 2001, 101, 757; (c) S. E. Denmark, N. Nakajima, O. -C. Nicaise, J.

2003, 42, 36. S. Yokoshima, H. Tokuyama, T. Fukuyama, Angew. Chem. Int. Ed. 2000, 39, 4073. C. Clarke, I. Fleming, J. M. D. Fortunak, P. T. Gallather, M. C. Honan, A. Mann, C. O. Nubling, P. R. Raithby, J. J. Wolff, Tetrahedron 1988, 44, 3931. K. D. Eom, J. V. Raman, H. Kim, J. K. Cha, J. Am. Chem. Soc. 2003, 125, 5415. (a) M. Shimazaki, H. Hara, K. -i. Tsuchihashi, Tetrahedron Lett. 1987, 28, 5891; (b) other reports on stereospecific 1,2-rearrangements; K. Ooi, K. Maruoka. H. Yamamoto, Org. Synth.

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