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By R.W. Hay, J.R. Dilworth, K.B. Nolan
The purpose of this sequence is to supply authoritative stories within the speedily increasing region of bioinorganic chemistry. The sequence will current "state of the paintings" experiences masking the full box of bioinorganic chemistry. the current quantity is the fourth within the sequence and covers the subjects: lithium in biology, the constitution and serve as of ceroplasmin, rhenium complexes in nuclear drugs, the anti-HIV job of macrocyclic polyamines and their steel complexes for dinuclear phosphoesterase enzymes.
Read or Download Perspectives on Bioinorganic Chemistry, Volume 4, Volume 4 PDF
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Extra resources for Perspectives on Bioinorganic Chemistry, Volume 4, Volume 4
Sample text
The effects of Li § upon this system have been reviewed in depth by Mork [ 131]. Animal studies originally demonstrated that Li § inhibits cAMP formation catalyzed by adenylate cyclase in a dose-dependent manner [132]. The level of cAMP in the urine of manic-depressive patients changes with mental state, being abnormally elevated during the "switch" period between depression and mania; it is proposed that Li*'s inhibitory effect upon adenylate cyclase activity may correct this abnormality. Subsequent research, in accord with the initial experiments, have shown that Li+'s interference with this second messenger system involves more than one inhibitory action.
The transport of Li § in plant cells has received little attention; its movement can be passive or mediated by Na § channels [249] and in some reports Li § actually blocks ion channels; for instance it inhibits voltage-dependent K § channels in Chara cells [250].
The increase in iodotyrosine-deiodinase activity is probably a response to the Li+-induced decrease in the concentration of thyroidal I-. Li + has no effect on the conversion of thyroxine to triiodothyronine. The overall effect of this competition between Li + and I- is, therefore, reduced levels of thyroid hormone in the presence of Li +. A therapeutic role for Li § taking advantage of this inhibitory effect of Li + on the thyroid, has been demonstrated in thyrotoxic patients by rapidly lowering the concentration of circulating thyroid hormone [ 183]; this may be beneficial in the short term treatment of hyperthyroidism.