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By Stanley Feldman Dr, Professor of Accident and Emergency Medicine John A Henry, Senior Lecturer in Anaesthesia Lakshman Karalliedde
Few chemical substances created by way of guy have brought on larger controversy than organophosphates. Conceived as pesticides, they've got additionally been built to develop into the main feared of chemical guns. The keep watch over of vectors of illnesses from which thousands die or are disabled is seriously depending on organophosphates, as are efforts to take care of nutrients creation within the face of out of control inhabitants progress, diminishing arable land and the opportunity of international warming. because the toxicity of organophosphates is non-specific, it has brought on unwell well-being and loss of life in guy, and has contributed to opposed ecological results.
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Butterworth-Heinemann; Oxford: 1992. p. 602-10. ISO. Progress in standardization. Annex 1 ISO common names for pesticides. Annex 3 ISO common names for pesticides. 1965. Geneva: International Organization for Standardization. ISO. International standard 1750. Geneva: 198l;International Organization for Standardization. A. Neurological syndromes of organophosphorus compounds. Adverse Drug Reactions and Acute Poisonings Review 1997;16:133—70. V. Muscarinic receptor subtypes: modulation of ion channels.
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OPS USED FOR PROPERTIES OTHER THAN ANTIChE ACTIVITY. There are a number of OP compounds that have found uses that do not depend upon antiChE activity. They can be divided into three groups. Group 1 comprises fairly typical antiChEs that have been found to have other useful properties, an example being the fungicide pyrazophos. Group 2 includes a number of compounds that have atypical structures and weak antiChE properties. They include the cotton defoliants, tri-S-butyl phosphorotrithioate and tri-S-butyl phosphorotrithioite as well as tri-ocresyl phosphate, used in jet engines; all three of these are inducers of OPIDP.