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By Ingo Weisse (auth.), Ingo Weisse, Otto Hockwin, Keith Green, Ramesh C. Tripathi (eds.)
On behalf of the editorial board and the organizing committee of the 4th congress of the foreign Society of Ocular Toxicology (I SOT), held in AnnecyNeyrier du Lac, France, October nine -13, 1994, we're happy to offer to the ocular toxicology neighborhood this listed quantity of our congress court cases. The 4th congress used to be designed basically to facilitate and replace the information in ocular electrophysiology and ocular pharmacokinetics, in either the medical and preclinical facets. the result of this 4th congress, tested during this quantity, is an invaluable contribution to the meth odology in either fields and may optimistically help in the overview and interpretation of ocular findings recorded in animal reviews on medicines and different chemical substances, for you to guard human wellbeing and fitness. surely, paintings at the mechanisms of ocular toxicology within the technique of pharmaceutical improvement needs to proceed and those court cases, embodying the provided papers, will upload to the information base. The editors, the congress organizing committee and the participants of the overseas Society of Ocular Toxicology thank the audio system who gave their time, wisdom, and services to help us during this undertaking. the subsequent manuscripts include the most substance of every of the platform displays and, occasionally, even more. in addition, our thank you visit all of the members coming from quite a number historical past- regulatory, educational and commercial -for their recognition and ideal contributions in the course of the discussion.
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The best characterized are the rd and rds strains. Retinal degenerations have also been reported in the rat. The best documented degeneration is seen in the ReS rat. The disease is a primary retinal pigment epitheliopathy. Failure of the RPE to phagocytize shed photoreceptor outer segments results in accumulation of membranous debris between retina and RPE and subsequent retinal atrophy in the early postnatal period. Retinal degenerations have occasionally been reported in other strains of rat that may not be inherited.