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By Thomas Nogrady, Donald F. Weaver
For the hot version of this article on medicinal chemistry and molecular pharmacology, the authors have commonly up to date the cloth take into consideration advances because the e-book of the second one variation in 1998. they've got further descriptions of recent concepts of modeling, functions of genomics in drug layout, cures for Alzheimer's and different illnesses, and rising issues like these of protein folding. another way, the final constitution has remained unchanged with chapters first offering the elemental ideas of medicinal chemistry after which purposes from a objective- founded perspective.
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Additional resources for Medicinal Chemistry: A Molecular and Biochemical Approach
Sample text
It should be emphasized that the mere sign (+ or −) of the optical rotation produced by an enantiomer is not biochemically decisive to the action of such a molecule. The absolute configuration of the compound in question must be considered; in modern organic chemistry the Cahn–Ingold–Prelog sequence rules are followed, and have increasingly replaced the ambiguous and obsolescent D and L designations for relative configuration. Again, the reader is referred to standard organic chemistry texts for details.
5 Structural Properties of Drug Molecules A drug molecule is a collection of molecular fragments held in a three-dimensional arrangement that determines and defines all of the properties of the drug molecules. Classical bioisosteres 1. Monovalent atoms or groups: NH2 OH CH3 PH2 SH Br i -Pr I 2. Bivalent atoms or groups: CH2 NH COCH2R CONHR 3. Trivalent atoms: CH P CI F H O CO2R S COSR N+ P+ N As 4. Tetravalent atoms: C Si Nonclassical bioisosteres 1. Functional group replacements: a. Halogens: X CF3 CN b.
Since this hydroxylated metabolite is pharmacologically active, the stereochemical circumstances of the activation process are crucial, not only for the extent of the activation but also for the rate of elimination of the metabolite. 1 Optical Isomers of Drugs Optical isomerism is the result of a dissymmetry in molecular substitution. The basic aspects of optical isomerism are discussed in various textbooks of organic chemistry. Optical isomers (enantiomers) may have different physiological activities from each other provided that their interaction with a receptor or some other effector structure involves the asymmetric carbon atom of the enantiomeric molecule and that the three different substituents on this carbon atom interact with the receptor.