Lab-on-Chips for Cellomics: Micro and Nanotechnologies for by Albert Berg, Helene Andersson

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By Albert Berg, Helene Andersson

This quantity is quantity completely devoted to microfabricated cell-based structures. it is going to supply readers with a short advent to the sphere in addition to with numerous particular examples of such Lab-on-Chip structures for cellomics functions. it is going to supply investigators notion for leading edge learn subject matters, while finish clients may be shocked concerning the big choice of recent and fascinating functions.

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Gravensen, J. Lichtenberg, D. Diamond, E. Verpoorte and N. de Rooij (2001) Chemical sensing using an integrated microfluidic system based on the Berthelot reaction, Sensors and Actuators B, 76, 235-243. , B. van der Schoot, S. Jeanneret and A. Manz (1994) 3-dimensional microflow manifolds for miniaturized chemical analysis systems, J. of Micromechanics and microengineering, 4, 246-256. , K. Fluri, K. Seiler, Z. Fan, C. Effenhauser and A. Manz (1993) Micromachning a miniaturized capillary electrophoresis-based chemical analysis system on chip, Science, 261, 895-897.

D. T. Woolley, T. Thorsen, R. F. A. Mathies (1998) High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates, Proc Natl Acad Sci U S A, 95, 2256-61. , A. Pisano and R. Muller (1993) Silicon processed microneedles, Transducers 93, 237. , N. Talbot, D. Liepmann and A. Pisano (2000) Microfabricated polysilicon microneedles for minimally invasive biomedical devices, Biomedical microdevices, 2, 295. Lebouitz, K. and A. Pisano (1998) Microneedles and microlancets fabricated using SOI wafers and isotropic etching, Microstructures and microfabrication systems IV, 235.

CONCLUSIONS After having proven the value of microfluidics for genetic and proteomic analysis, this chapter illustrates it is also a very useful concept for cell analysis. Most of the cited work derives from the past 5 years, with a clear trend towards single cell analysis. Hence, the most important development in 1. Microfluidic Devices for Cellomics 17 cellomics is the possibility to treat and analyze single living cells. It is clear that with the recent technological developments many life-sciences researchers obtain a very powerful tool for detailed cellular studies.

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