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Additional resources for Induction of Thyroid Cancer by Ionizing Radiation (N C R P Report)
Sample text
Effectwe Half Time in the Thymid -Tc '='I 'I '"I ' SI '"I ' 9 '"I 'From (Snyder, 1976) with the exception of that for '"I which was determined directly from the '"I: Nuclear Data Sheets (1975). bAssuming a biological half time of 90 days for iodine and of 4 hours for TC pertechnetate. , 1970) up to 108 h y s (Van Dilla and Fulwyler, 1964). For -Tc, no comprehensive reference was found One MIRD Report (1976) discusses multiple components with the initial clearance having a half-time of 1 to 2 hours; extrapolation of data from Fragu et al.
For the production of thyroid carcinomas, the two radiation types appeared to be of equal effectiveness a t all three doses although the results did not preclude a relative effectiveness of l3'I of as little as one-third compared to external radiation. The differences in effectiveness observed in the study of Lee et al. (1982) and the earlier rat studies may reflect differences in age at exposure (those in the more recent study were generally 2 to 6 weeks younger), and for Doniach's work, the strain of rat used.
3 case), although the difference between the observed and expected cases is not considered significant. 2 Non-therapeutic Exposures to 13'1 Holm et a1 (1980a, 1981) reported a retrospective analysis of outcome in 10,133 subjects exposed to diagnostic administration of 13'1 (total 28 / EXPERIENCE AFTER EXPOSURE TO IODINE-131 less than 1mCi) for suspected thyroid disease. The population included 8047 females (79 percent) and 2086 males (21 percent) with a mean age of 44 years for both sexes. Of the 10,133 subjects, 9639 were over the age of 20 years a t exposure and 494 were less than 20 years of age.