
By Alan R. Katritzky
This re-creation is designed to supply a one-volume total photograph of the topic of heterocyclic chemistry.
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Extra resources for Handbook of Heterocyclic Chemistry, Second Edition
Sample text
The cyclic AMP surge may also be part of the mechanism that together with PKB/AKT signals from adhesion-activated $1-integrins suppresses the E2F1/p53mediated apoptogenic arm of c-Myc action. 86 The activated PKA then phosphorylates BAD protein’s Ser112, which inactivates this apoptosis-promoting protein. A checkpoint to pass “We know that cells have a well-organized set of molecular controls that govern their progress through the cell cycle. In particular, there is a series of ‘checkpoints’ that each must successfully negotiate before it can proceed to division.
128. Bischoff FR, Ponstingl H. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 1991; 354: 80–82. 129.
Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: inhibition by proliferating osteoblasts and osteosarcoma cells. J Cell Biochem 1997; 66: 141–152. 29. Whitfield JF, Morley P, Willick GE. The Parathyroid Hormone: An Unexpected Bone Builder for Treating Osteoporosis. Austin, RG Landes Company, 1998. 30. Peters J-M. SCF and APC the Yin and Yang of cell cycle regulated proteolysis. Curr Opin Cell Biol 1998; 10: 759–768. 31. March KL, Wilensky RL, Roeske RW, et al.