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By Dorothy L. Rosenthal MD, FIAC, Stephen S. Raab MD (auth.)
The Essentials in Cytopathology sequence publishes generously illustrated and easy publications with over a hundred complete colour pictures that illustrate ideas and perform in Cytopathology for pathologists and clinicians.
Cytologic Detection of Urothelial Lesions through Dorothy L. Rosenthal, MD and Stephen S. Raab, MD is the second one quantity within the Series. This quantity will current an easy method of facing mobile samples from the urinary tract.
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Extra resources for Cytologic Detection of Urothelial Lesions
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600x) 28 2. 6. Reactive Urothelial Cells—catheterized urine: A cluster of benign, degenerated urothelial cells is seen adjacent to a crystal. The more preserved urothelial cells contain enlarged nuclei that are not hyperchromatic and may be seen at the edges of the large cluster. For the most part, the nuclei are small and hyperchromatic. 7. Atypical Urothelial Cells—catheterized urine: Two large clusters of atypical urothelial cells are seen. The cells exhibit an increased nuclear to cytoplasmic ratio although the nuclei are not markedly hyperchromatic.
The cells exhibit only mildly increased nuclear to cytoplasmic ratios and many of the cells contain abundant cytoplasm. Note that the nuclear size is smaller than the size of intermediate squamous cells. (600x) 42 2. 20. Polyoma Virus—voided urine: If this is a rare cell in the specimen, then one can presume a viral infection. However, nuclear changes could be degeration in a cell from a high grade carcinoma and warrant careful follow-up. 21. Polyoma Virus—voided urine: An infected cell displays overall cell enlargement, high NC ratio, and ground glass nucleus with marginated chromatin.
Herpes Simplex Infection—urethral brushing: Intranuclear inclusions, multinucleation and nuclear molding typify Herpes infection anywhere in the body. This patient had AIDS, and died of systemic Herpes infection. (400x) 46 2. 24. Cytomegalovirus Infected Urothelial Cells—voided urine: In urines, viral cytopathic effect is characteristically similar to CMV infections in other body sites. Compare these enlarged nuclei with distinct intranuclear inclusions and perinuclear clearing with the nuclear changes produced by polyoma virus infection.