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While there was a temptation to quickly arrive at a recommendation to terminate the trial, the DMC spent considerable time probing the interim data in the study reports. Some suspicious patterns were detected, including a few important laboratory and toxicity measures that revealed trends in the opposite direction to what might have been expected. The DMC had a dilemma. With such unfavorable results, it would be important to promptly inform the Steering Committee to enable them to spare future patients from being randomized to receive a potentially harmful treatment.
Thus, prior to the initiation of the trial, the DMC should make itself aware of the data management and quality control procedures that will be used. , 1995). The complexities of clinical trials in AIDS, which have been greatly increased by intense pressure for obtaining rapid answers, made the development of appropriate systems and procedures within the ACTG for data management and quality control even more complicated than usual. Initially, the ACTG DMC had considerable difficulties understanding how data were being managed, what information on safety and efficacy could be provided on a timely basis, and how accurate it would be.
Initially, the ACTG DMC had considerable difficulties understanding how data were being managed, what information on safety and efficacy could be provided on a timely basis, and how accurate it would be. After the DMC spent much of its first two quarterly meetings in early 1987 probing issues on data quality, NIAID decided to arrange for some DMC members to make a site visit of the AIDS Clinical Trials Data Coordinating Center (DCC). This visit had a number of beneficial effects, for the DCC as well as for the DMC.