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Extra resources for Toxicology and Experimental Models. Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
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001) between the total plasma clearance of NT and the metabolic clearance by E-10-hydroxylation. , 1981). A considerably larger sample of subjects has to be examined to clarify the genetic mechanisms involved. By contrast, there was no meaningful correlation between the debrisoquine/4-hydroxydebrisoquine ratio and the salivary clearance of antipyrine (Fig. 2 ) , nor did the clearance of antipyrine through the various pathways indicated in Fig. 1 correlate to the debrisoquine ratio (Eichelbaum, Bertilsson & Säwe, unpublished data).
C. G. Watanabe (1981). Applica tion of pharmacokinetics and metabolism in extrapolation of toxicological data from animals to man. Tokyo, 8th International Congress of Pharmacology, July 19-24, 1981. Japanese Pharmacological Society and Science Council of Japan, Abstracts, p. 27. P. Agarwal, and S. Harada (1980). Genetic studies on alcohol-metabolizing enzymes: Detection of isozymes in human hair roots. Enzyme, 25, 281-286. Greim, H. (1979). Personal communication. Henschler, D. (1977). Mechanismen der Aktivierung chlorierter aliphatischer Verbindungen - experimentelle Zugänge und klinische Bedeutung.
C1in. Pharmaco1. , 27, 711-725. , and D. Neubert (1980). Significance of organ culture techniques for evaluation of prenatal toxicology. Arch. , 45, 161-187. 50 H. Frohberg Beck, F. (1981). Lessons from studies in animals for the evalu ation of human risk from teratogenic agents. In S. ), 8th International Congress of Pharmacology, Pergamon Press, Oxford. G. J. Laib, and H. Ottenwälder (1980). Binding kinetics of vinyl chloride and vinyl bromide at very low doses. Arch. , Suppl. 3, 129-142. B.