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By Gary W Miller
The Exposome: A Primer is the 1st e-book devoted to exposomics, detailing the aim and scope of this rising box of analysis, its functional purposes and the way it enhances a large variety of disciplines. Genetic factors account for as much as a 3rd of all advanced ailments. (As genomic ways enhance, this can be prone to rise.) Environmental elements additionally impact human ailment yet, not like with genetics, there is not any usual or systematic approach to degree the effect of environmental exposures. The exposome is an rising idea that hopes to handle this, measuring the results of life-long environmental exposures on health and wellbeing and the way those exposures can impact affliction.
This systematic creation considers themes of coping with and integrating exposome facts (including maps, versions, computation, and platforms biology), "-omics"-based applied sciences, and extra. either scholars and scientists in disciplines together with toxicology, environmental well-being, epidemiology, and public future health will take advantage of this rigorous but readable overview.
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Etymologically, it should have been toxicotranscriptomics, as it was using microarrays to assess the effects of toxic chemicals on gene expression. More recently, some in the field have proposed that toxicogenomics should include any -omic data that assesses the toxicological consequences (more detail in Chapter 4). If one accepts the term to encompass all -omic technologies that inform the field of toxicology then it clearly falls under the larger umbrella of the exposome. 5 EPIGENOMICS By examining the epigenetic modifications discussed in Chapter 2 at a genome-wide scale, epigenomics provides a global measure of altered DNA regulation.
We must focus on verifiable outcomes that have the potential to impact human health. We also want to take advantage of the data and tools resulting from other relevant and validated omic-based technologies. While comparisons with the genome, transcriptome, and proteome are welcome, we would do best to avoid comparison with the ridiculome. 11 DISCUSSION QUESTIONS If study of the human genome gave rise to genomics, does the human exposome give rise to a new field of exposomics? Should it be a separate field or should the exposome serve as an organizing framework for the cornucopia of -omic technologies?
It will be especially attractive to be able to layer these metabolomic patterns onto the proteomic and transcriptomic patterns to see how well they correlate. Such analyses will require systems and computational biology approaches that will be discussed in Chapter 5. 7 MICROBIOME The microbiome consists of the millions of microbial organisms that exist within the confines of the human body. Primary among these are those that reside in the intestines of the digestive system, but microbes also reside within our urogenital systems, the integumentary system, and also in our noses and mouths.