Ototoxicity by Peter S. Roland, John A., M.D. Rutka,

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By Peter S. Roland, John A., M.D. Rutka,

'Ototoxicity' is a compendium of data at the ototoxic strength of clinically helpful medications. every one part of this thorough textual content is written via a number one authority within the box. The booklet experiences the real sessions of medicines identified to reason ototoxicity and their mechanisms. scientific manifestations, what's recognized approximately pathophysiology, concepts for prevention and remedy, and medical-legal matters for every classification of compounds are reviewed. Auditory and vestibular tracking and new healing techniques which can hinder or reduce ototoxicity are highlighted as well as discussing fresh advances in protecting treatment. additionally incorporated is the healing use of the ototoxic homes of aminoglycosides within the medical remedy of internal ear disorder.

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The silent current. Biophys J 1990;57:1253–68. 76. Spicer SS, Schulte BA. The fine structure of spiral ligament cells relates to ion return to the stria and varies with place-frequency. Hear Res 1996;100: 80–100. 77. Henson MM, Henson OW Jr, Jenkins DB. The attachment of the spiral ligament to the cochlear wall: anchoring cells and the creation of tension. Hear Res 1984;16:231–42. 78. Salt AN, Melichar I, Thalmann R. Mechanisms of endocochlear potential generation by stria vascularis. Laryngoscope 1987;97:984–91.

Injury to the endorgans as might occur in systemic aminoglycoside vestibulotoxicity causes a bilateral loss of function that tends to be electrically symmetric at the level of the vestibular nuclei in the brainstem. Instead the patient tends to complain of oscillopsia and imbalance. The gait is typically broad-based and ataxic, especially with eyes closed. Falls are not infrequent and in many instances SPECIAL CLINICAL TESTS OF VESTIBULAR FUNCTION The following clinical tests are used at the bedside in the assessment of vestibular function and are specific for the VOR.

86. 87. 88. 89. 90. 91. 92. 93. the administration of the diuretic furosemide. Clin Otolaryngol 1976;1:211–9. Tasaki I, Davis H, Eldredge DH. Exploration of cochlear potentials in guinea pig with a microelectrode. J Acoust Soc Am 1954;26:765–73. Slepecky NB, Cefaratti LK, Yoo TJ. Type II and type IX collagen form heterotypic fibers in the tectorial membrane of the inner ear. Matrix 1992;12: 80–96. Møller AR. Sensory systems. San Diego: Academic Press; 2003. p. 63–72. Wever EG, Bray CW. Action currents in the auditory nerve in response to acoustical stimulation.

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