Nutritional Toxicology. Volume 3 by John N. Hathcock

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And Silbergeld, Ε. K. (1979). Erythrosin Β inhibits dopamine uptake in rat caudate synaptosomes. Science 205, 4 1 0 - 4 1 2 . Laties, V. , and Wood, R. W. (1986). Schedule-controlled behavior in behavioral toxicology, in "Neurobehavioral Toxicology" (Z. ), pp. 6 9 - 7 3 . The Johns Hopkins Univ. Press, Baltimore. Levitan, J. (1977). Food, drug and cosmetic dyes: Biological effects related to lipid solubility. Proc. Natl. Acad. Sci. A. 74, 2 9 1 4 - 2 9 1 8 . Lewin, R. (1987). Environmental hypothesis for brain diseases strengthened by new data.

Although behavioral observation requires more time and manpower than automated procedures, it is much more flexible and sensitive in detecting distinct patterns of behavior associated with particular toxicants. , 1977), and behavioral observation can be combined with in vivo cerebral dialysis to yield a powerful way of correlating biochemical and behavioral changes. Locomotor activity is probably the most frequently used behavioral screen for detecting neurotoxicity, and there are a variety of automated methods for recording it.

7, pp. 3 - 3 5 . Plenum, New York. Mailman, R. B. (1987). Mechanisms of CNS injury in behavioral dysfunction. Neurotoxicol. Teratol. 9, 4 1 7 - 4 2 6 . Mailman, R. B . , and DeHaven, D. L. (1984). Responses of neurotransmitter systems to toxicant exposure. In "Cellular and Molecular Neurotoxicology" (T. ), pp. 2 0 7 - 2 2 4 . Raven, New York. Mailman, R. B . , and Lewis, M. H. (1981). Food additives and developmental disorders: The case of erythrosin (FDC red # 3 ) , or guilty until proven innocent.

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