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By Robert H. Miller (auth.), Ian D. Duncan, Robin J M Franklin (eds.)
Myelin fix and Neuroprotection in a number of Sclerosis offers an up-date at the translational strength of marketing remyelination in a number of sclerosis (MS). a couple of study frontiers nonetheless exist during this tough disorder. The reason is still elusive, combating breakthroughs in its prevention. The circulate in the direction of oral immunomodulatory cures has been a big boost, as has the discovering of recent genes associated with susceptibility which may open the door to new healing techniques. even if, a frontier that has been making major strides in recent times has been that surrounding the neurobiology of myelin regeneration and axon safety: such were the advances that scientific translation is at the cusp of being accomplished. vast techniques to healing enhancement of remyelination are envisaged: selling endogenous remyelination through focusing on cells found in the CNS, or, exchanging misplaced myelinating cells from exogenous resources. present study on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the best way towards establishing this new translational frontier.
Professor Duncan and Professor Franklin have assembled a vast workforce of specialists within the fields of glial mobile biology, neuropathology, radiology and scientific neurology to supply the historical past towards taking remyelination from experimented types into MS sufferers.
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Neuron 59:581–595 Cai J, Qi Y, Hu X, Tan M, Liu Z et al (2005) Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of on Nkx6 regulation and Shh signaling. Neuron 45:41–53 Calver AR, Hall AC, Yu WP, Walsh FS, Heath JK et al (1998) Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron 20:869–882 Cheng X, Wang Y, He Q, Qiu M, Whittemore SR, Cao Q (2007) Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells.
Neurochem Res 34:169–181 Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang RZ, Hall AK, Miller RH (2007) Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Annals of Neurology, 62(3):288–300. PMID: 17696121 Gao L, Miller RH (2006) Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons. J Neurosci 29:7619–7628 Garcion E, Faissner A, ffrench-Constant C (2001) Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration.
J Neurosci 30:16383–16390 Tripathi RB, Clarke LE, Burzomato V, Kessaris N, Anderson PN et al (2011) Dorsally and ventrally derived oligodendrocytes have similar electrical properties but myelinate preferred tracts. J Neurosci 31:6809–6819 Tsai H-H, Miller RH (2002) Glial cell migration directed by axon guidance cues. Trends Neurosci 25:173–175 Tsai H, Frost E, Robinson S, Ransohoff R, Sussman C et al (2002) The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration.