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By Jeremy I Levin; David P Rotella; Royal Society of Chemistry (Great Britain)
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8 O 79. Hanessian #(S) 35 Structures 66 to 79; Cyclic Histone Deacetylase Inhibitors. 140 View Online 10:41:00. 1039/9781782623113-00001 Bioactive Macrocycles from Nature 23 Contemporaneously with the determination of the MOA of trapoxin, a novel cytotoxic microbial agent was reported by Ueda et al. 143 FK228 was recommended for FDA approval in September of 2009 as a treatment for cutaneous T-cell lymphoma and was launched in the USA in March, 2010. However, FK228 was only the beginning of the isolation, identification and often, total synthesis of a number of depsipeptides all containing the dithio bridge and all acting as prodrugs for interaction with various isotypes of HDACs.