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By Kuan-Teh Jeang (Eds.)
The cumulative dying toll from AIDS has reached 16.3 million members, and greater than 33 million people are at present residing with HIV-1. even though it is without doubt one of the most-widely studied viruses, many mysteries stay approximately this pathogen. during this accomplished two-volume set, HIV-1: Molecular Biology and Pathogenesis, major investigators in HIV study current a well timed photo of the molecular mechanisms which consultant HIV-1 expression and replication and supply the most up-tp-date scientific options for battling this virus. Twenty-six groups of specialists get to the bottom of structure-function interactions of HIV-1 with host cells and the ensuing pathological outcomes, overview thoughts fo therapy, and describe ongoing growth in constructing animal versions and prophylactic vaccines.The volumes, protecting viral mechanisms and scientific purposes, respectively, are written by way of a world choice of AIDS expers from North the US, Europe, Australia, and Asia. Key gains* certain insights into viral packaging, expression, and meeting* Mechanistic realizing of ways HIV interacts with receptors and infects cells* Delineation of virally encoded regulatory methods specific to HIV* medical Applications:* An up-to-date evaluation of present chemotherapeutics for HIV* New options within the discovery and layout of novel anti-HIV medicinal drugs* the newest advancements in HIV-vaccine study
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1995). , 1999), indicate that the major packaging signal of HIV-2 is in a region 5Ј to the splice donor and that the region between the splice donor and the Gag ATG makes a definite but relatively minor contribution. , 1998). Capture of spliced HIV-2 RNA by HIV-1 suggests that a fully functional signal exists in the region 5Ј to the splice donor. , 1993) and, in one of these (Rizvi), SIV RNA was packaged by HIV-1 as well. , 1998) and the situation may be analogous to HIV-1 in which context-dependent components of the packaging signal exist 5Ј and 3Ј to the splice donor.