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"Based at the First overseas Symposium on Metals and Genetics held lately on the clinic for unwell little ones in Toronto, Ontario, Canada. the one publication of its sort to target the consequences of metals on DNA. presents up to date details on new advancements within the box and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity."
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Ascorbate is required as a vitamin in the diet for the Osteogenic Disorder Shionogi (ODS) rat, making it an ideal in vivo animal model in which to study the effect of ascorbate on Cr(VI)-induced genotoxicity. Ascorbate was required for binding of chromium to DNA in liver of ODS rats treated with Cr(VI). Little hepatic Cr-DNA binding occurred upon Cr(VI) treatment of ascorbate-deficient ODS rats fed 5 ppm ascorbate in the diet. High Cr-DNA binding was observed in liver of ODS rats fed200 ppm ascorbate in the diet, a level which supports normal growth, andlower but significant Cr-DNA binding was observed at800 pprn dietary ascorbate.
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