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By Jörg König (auth.), Martin F. Fromm, Richard B. Kim (eds.)
It is more and more famous that numerous transporter proteins are expressed during the physique and verify absorption, tissue distribution, biliary and renal removing of endogenous compounds and medication and drug results. This booklet will supply an summary at the transporter households that are most vital for drug remedy. so much chapters will specialise in one transporter relations highlighting tissue expression, substrates, inhibitors, knock-out mouse types and medical studies.
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Extra info for Drug Transporters
Sample text
8 Drug/Drug Interactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Pharmacogenomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 6 Urate Transporter 1 (URAT1; Urat1/Rst, Gene Name SLC22A12/Slc22a12) . . . . . . 1 Cloning, Structure . . . . . . . . . . . . . . . . . . . . . .
3 Immunolocalization of OAT4 Protein . . . . . . . . . . . . . . . . . . . . . . . 4 Species Differences, Age and Gender Dependence of Expression . . . . . . . . . 5 Factors Influencing Activity and Abundance of OAT4 . . . . . . . . . . . . . . 6 Substrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Inhibitors . . . . . . . . . . . . . . . . . . . . .
9 Pharmacogenomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 32 32 34 36 36 37 39 49 50 51 52 52 52 53 53 54 54 58 58 58 58 58 59 59 60 60 61 69 69 71 G. C. F. B. 1007/978-3-642-14541-4_2, # Springer-Verlag Berlin Heidelberg 2011 29 30 G. C. Burckhardt 5 Organic Anion Transporter 4 (OAT4, Gene Name SLC22A11) . . . . . . . . . . . . . 1 Cloning, Structure . . . . . . . . . . . . .