Chemical Consequences by Scott Frickel

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By Scott Frickel

Frickel (sociology, Tulane U.) examines a scientists' social move that turned the learn of genetic toxicology. As a gaggle of scientists grew to become acutely aware that man made chemical substances may perhaps swap genetic constructions, they grew to become activists, constructing a community of researchers and politicians, constructing investment, and publishing articles and books that got here to outline environmental wellbeing and fitness technology. Frickel explains how researchers on mutations needed to conscientiously differentiate these because of man made chemical compounds, constructing new tools of buying and reading information. the consequences have been so alarming, and convincing, that the scientists have been in a position to enlist assistance from others with services right into a targeted social flow in keeping with facts instead of mere emotional response; they then started to paintings in the political enviornment to notify those that made environmental coverage. Appendices comprise an inventory of scientists interviewed during this research and a timeline of occasions from the beginnings of the stream in 1964 via 1976.

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Drosophila’s usefulness to geneticists depended on the development of a laboratory production system with the capacity to produce spontaneous mutants in sufficient numbers to permit quantitative genetic analysis. In order to construct the “standard” fly, the fly production process had to be improved, and those improvements also had to be standardized and disseminated. During the 1910s and 1920s, Thomas Hunt Morgan’s “Drosophilists” at Columbia University, after considerable experimental and organizational effort, succeeded at ratcheting up the rate at which mutant and wild-type flies were bred and crossed.

Data for this project derive from various sources. I have consulted numerous published documents, including scientific journal articles, editorials, “insider” histories, newsletters, conference proceedings, government reports, transcripts from congressional hearings, trade magazines, newspapers, and scientific information databases. Documents from archive collections, administrative records, departmental or program files, and scientists’ personal files have also been indispensable sources of primary data.

To be sure, the potential economic relevance of chemical mutagens was not lost on geneticists working in select agricultural and biomedical sciences. In those research contexts, scientists tended to select mutagens with an eye toward maximizing the production of economically beneficial mutations, each following a logic tailored to a particular set of research and production goals. At medical schools, hospitals, and the National Cancer Institute, scientists turned to chemical mutagens in the treatment of malignant tumors.

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