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By Robert A. Maes, Hans Brandenberger
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Extra resources for Analytical toxicology for clinical, forensic, and pharmaceutical chemists
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For evaluating a loading dose or a steady state serum concentration). Based on clinical criteria, 30 % of the requests were justified. The majority of the requests (56 %) were not justified because measurements were made within 3 days of starting the drug or changing the dose. Several patients actually developed phenytoin toxicity due to unwarranted dose changes based on pre steady-state serum concentrations which were assumed to be at steady state. The Italian Collaborative Group on Utilization of TDM in Hospital Departments (92) reviewed data on TDM services in 28 general hospital wards.
1976) The relation of anticonvulsant drug levels to complete seizure control. J. Clin. Pharmacol. 16, 51-59. 35. Reynolds, E. H.. Shorvon, S. I. et. al. (1981) Phenytoin monotherapy for epilepsy: a long term prospective study, assisted by serum level monitoring, in previously untreated patients. Epilepsia 22, 475-488. 36. Cobos, J. E.
26 Therapeutic Drug Monitoring References 1. Friedman, H. J. (1986) Rational therapeutic drug monitoring. JAMA 256, 2227-2233. 2. J. & Feely, J. (1988) Practical clinical pharmacology. Therapeutic drug monitoring and clinical trials. Br. Med. J. 296, 1110-1114. 3. F. S. (1988) Therapeutic drug monitoring. Clin. Pharmacol. Ther. 43, 345-353. 4. Richens, A. & Marks, V. (1981) Therapeutic drug monitoring, Churchill Livingston, Edinburgh. 5. Gal, P. (1988) Therapeutic drug monitoring in neonates: problems and issues.