2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th by John S. Bradley MD, John D. Nelson MD Emeritus, Dr.

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By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

This bestselling and common source on pediatric antimicrobial treatment offers fast entry to trustworthy concepts for remedy of all infectious illnesses in children.

For every one sickness, the authors supply a observation to assist healthiness care companies decide on the simplest of all antimicrobial offerings. The inquiring health professional can instantly hyperlink to the facts for the advice within the booklet or cellular model. Drug descriptions disguise all antimicrobial brokers on hand this day and contain whole information regarding dosing regimens.

In reaction to starting to be issues approximately overuse of antibiotics, the publication contains directions on while to not prescribe antimicrobials.

Key positive factors in nineteenth Edition!

- up to date information about the power and the extent of facts for all therapy techniques

- New bankruptcy on antibiotic treatment for overweight kids

- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection

- comprises therapy of parasitic infections and tropical medication.

- up to date anti-infective drug directory, entire with formulations and dosages.

- Balanced details on protection, efficacy and tolerability with information on charges and availability of substances

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Extra info for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition

Example text

Some experts advocate providing a prescription to parents, but waiting 1–2 days before treating mild cases. 73 2012–2013 Nelson’s Pediatric Antimicrobial Therapy — 47 – Bacterial (swimmer’s ear) (P aeruginosa, S aureus, including CA-MRSA)65,66 Clinical Diagnosis Therapy (evidence grade) Comments Otitis media, acute (cont) – Newborns See Chapter 5. – Infants and children (pneumococcus, H influenzae non-type b, Moraxella most common)73–75 Usual therapy: amoxicillin 90 mg/kg/day PO div bid; See Chapter 11 for dosages.

Antibiotic recommendations for CA-MRSA should be used for empiric therapy when CA-MRSA is suspected and for documented CA-MRSA infections, while “standard” recommendations refer to treatment of MSSA. During the past 2 years, clindamycin resistance in MRSA has increased to 40% in some areas, but remained stable at 5% in others. Please check your local susceptibility data for S aureus before using clindamycin for empiric therapy. For MSSA, oxacillin/nafcillin are considered equivalent agents. Adenitis, acute bacterial1–7 (S aureus, including CA-MRSA, and group A streptococcus) Empiric IV therapy: Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (AI) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h OR vancomycin 40 mg/kg/day IV q8h (BII) May need surgical drainage For oral therapy for MSSA: cephalexin OR cloxacillin; for CA-MRSA: clindamycin, TMP/SMX, or linezolid For group A strep: amoxicillin Total IV plus PO therapy for 7–10 days Adenitis, nontuberculous (atypical) mycobacterial8–11 Excision usually curative (BII); azithromycin PO OR clarithromycin PO for 6–12 wk (with or without rifampin) if susceptible (BII) Antibiotic susceptibility patterns are quite variable; cultures should guide therapy; medical therapy 60%–70% effective.

Treatment course for 10–14 days after surgical drainage, up to 21 days. CT scan to confirm cure (BIII). – Associated with entry site lesion on skin (S aureus, including CA-MRSA, group A streptococcus) Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (BII) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or vancomycin 40 mg/kg/day IV q8h (BIII) Oral antistaphylococcal antibiotic for less severe infection; treatment course for 7–10 days – Idiopathic (no entry site) in unimmunized infants: pneumococcal or H influenzae type b Ceftriaxone 50 mg/kg/day q24h OR cefotaxime 100–150 mg/kg/day IV, IM div q8h OR cefuroxime 150 mg/kg/day IV div q8h (AII) Treatment course for 7–10 days; rule out meningitis; alternative: other 2nd, 3rd, or 4th generation cephalosporins or chloramphenicol – Periorbital swelling, non- tender (usually associated with sinusitis), sinus pathogens rarely may erode anteriorly causing cellulitis Ceftriaxone 50 mg/kg/day q24h OR cefotaxime 100–150 mg/kg/day IV, IM div q8h OR cefuroxime 150 mg/kg/day IV div q8h (BIII) ADD clindamycin 30 mg/kg/day IV div q8h for more severe infection with suspect S aureus including CA-MRSA or for chronic sinusitis (covers anaerobes) (AIII) For oral convalescent antibiotic therapy, see Sinusitis, acute; total treatment course of 21 days or 7 days after resolution of symptoms.

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