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By Larry K. Golightly PharmD, BCPS, Isaac Teitelbaum MD, FACP (auth.), Larry K. Golightly, Isaac Teitelbaum, Tyree H. Kiser, Dimitriy A. Levin, Gerard R. Barber, Michael A. Jones, Nancy M. Stolpman, Katherine S. Lundin (eds.)
As the inhabitants of sufferers with acute or power kidney sickness grows, healthcare execs desire a source that optimizes drug effectiveness whereas minimizing strength toxicity. Renal Pharmacotherapy is a entire directory of dosage ideas for sufferers with compromised renal functionality. This up to date and evidence-based reference closes a number of pointed out wisdom gaps relating medicines eradicated by means of the kidneys.
Conveniently indexed alphabetically by means of known drug identify, every one drug has its personal face web page that includes general dosing levels, substitute dosing alterations by means of strata of renal functionality, particular dosing for dialysis and different dosing schemes.
This paintings will fulfill the dosing details wishes of busy physicians taken with pharmacotherapy for sufferers with kidney illness, in addition to pharmacists, nurses and students.
Read or Download Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidneys PDF
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Extra info for Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidneys
Sample text
2005;47:51–9. Turnheim K, Drivanek P, Oberbauer R. Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects. Br J Clin Pharmacol. 1999;48:501–9. Zyloprim® tablet [package insert]. San Diego CA: Prometheus Laboratories Inc; 2003. 28 Dosage Adjustment of Medications Eliminated by the Kidneys Allopurinol/Zyloprim®, Aloprim® {Anti-gout; xanthine oxidase inhibitor} Usual initial dose: 200 mg/m2 orally or IV Usual maintenance dose: 200–400 mg/m2/day orally or IV Typical maximum dose: 600 mg/day Proportion eliminated unchanged: 10 % (plus 80 % of each dose as pharmacologically active primary metabolite, oxypurinol) Adjustment for Kidney Disease FDA-approved product labeling: Alternative adjustment: CrCL 10–20 mL/min 200 mg orally or IV once daily CrCL 3–10 mL/min 100 mg orally or IV once daily CrCL <3 mL/min 100 mg/day orally or IV at extended intervals GFR >50 mL/min 200 mg orally or IV once daily GFR 10–50 mL/min 150 mg orally or IV once daily GFR <10 mL/min 100 mg orally or IV once daily or 150 mg orally every 48 h Hemodialysis 100 mg orally or IV once daily or 150 mg orally every 48 h; administer supplemental half dose (50 %) after dialysis CAPD Data not available CRRT 150 mg enterally or IV once daily 29 Dosage Adjustment of Medications Eliminated by the Kidneys Almotriptan - Selected References Axert® tablet [package insert].
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